The benefits of probiotics for human health have been discussed for decades. Probiotics are non-pathogenic organisms which, when administered in an adequate amount, interact directly or indirectly with pathogens in the intestine, resulting in a more natural method for restoring the microbiota and conferring a health benefit to the host. At least some of the probiotic bacteria used in various probiotic products may colonize the oral cavity during the time they are in use; thus, the effects of probiotic bacteria in the oral cavity are important to understand. Probiotic bacteria seem to affect both oral microbiota and immune responses. Several investigators have also suggested probiotics for oral health purposes. Interestingly, probiotics are also suggested to increase the lifetime of voice prosthesis by inhibiting the adhesion of unwanted microbes. Solve this problem we have a probiotic Ayu shot.