The two major components of a pharmaceutical formulation are drug and excipients. Though considered inert, excipients can dynamically cause instability in formulation by interacting with the drug. Thus, to develop a stable formulation, a drug excipient compatibility study (DECS) is being conducted prior to formulation development which assists in selection of the suitable excipients. However, the traditional DECS is a time-consuming process where drug & excipients are mixed and charged on stability for 3 months which causes a significant delay in the drug development cycle. Therefore, a novel approach is proposed which will be time-saving and effective in investigating the appropriate excipients by increasing intimate contact between drug and excipients up to multi folds due to the reduction of drug particle size. The developed approach will produce the results within weeks thereby reducing the timeline of 3 months to 1 week and ultimately accelerating the drug development process.